HEALTHY LIVING
A genetic connection to kidney disease
How APOL1-mediated kidney disease can impact you, your kidneys and your family
(Family Features) A genetic condition that can cause kidney failure, APOL1-mediated kidney disease (AMKD) represents a group of kidney diseases associated with mutations (changes or variants) in the apolipoprotein L1 (APOL1) genes.
Typically, the APOL1 genes – of which every person has two, one from each parent – create proteins that play a role in immunity. However, some people are born with mutations in one or both genes, and having mutations in both can increase the risk of developing kidney disease and even kidney failure.
In honor of National AMKD Awareness Day on April 30, consider this information from the experts at the American Kidney Fund to better understand the disease and become APOL1 aware.
Understanding Risk Factors
Research shows Black people with kidney disease are more likely to develop kidney failure than any other racial or ethnic group. The reasons for these health disparities include social determinants of health, a higher burden of diabetes and high blood pressure in the Black community, barriers to health care access and genetics.
The APOL1 gene mutations evolved over the past 3,000-10,000 years in people who lived in western and central Africa and are associated with increased protection from a parasite carried by the tse tse fly that causes African sleeping sickness. While protecting from one disease, the mutation – if inherited in both APOL1 genes – is more likely to lead to kidney disease in those of certain African descent, including people who identify as Black, African American, Afro-Caribbean or Latina or Latino.
In fact, an estimated 13% of Black Americans have two APOL1 gene mutations, according to the American Kidney Fund. While not everyone who has two APOL1 mutations will get kidney disease, there is a 1 in 5 chance they will go on to develop AMKD.
Identifying Symptoms
If you have kidney damage, symptoms may not occur until your kidneys are close to failing. As kidney damage worsens, one or more of these symptoms may occur:
- Protein in urine
- Swelling in legs or weight gain
- Feeling weak or tired
- High blood pressure
Should these symptoms occur and you have a family history of kidney disease, talk to a doctor about getting tested for kidney disease, as testing is the only way to determine kidney function. AMKD can cause damage to parts of the kidney that filter blood or, in some cases, cause cells in the kidneys to die, which can lead to damage and scarring that may eventually lead to kidney failure.
Getting a Diagnosis
The only way to know if you have APOL1 gene mutations is to do genetic testing via a blood or saliva sample. Genetic testing may be considered if you have kidney disease and don’t know the cause or if you’re considering donating a kidney. Testing may also be considered if a family member is a carrier for the mutation. If you have questions about genetic testing, discuss your options with a doctor or ask for a referral to a genetic counselor.
Taking Steps to Prevent Kidney Disease
There are currently no treatments available for AMKD. However, there are steps you can take to protect your kidneys and promote general health. Work with your doctor to create a plan to prevent or delay the progression of kidney disease, which may include:
- Doctor visits to check how your kidneys are working through urine and blood tests
- Checking for and managing diabetes and high blood pressure
- A healthy eating plan, which may involve limiting things like sodium (salt)
- Taking prescription medications as directed
- Being active at least 30 minutes each day of the week
- Quitting smoking or using tobacco
If you have the APOL1 gene mutations, you may be able to take part in clinical trials. Trials could provide an opportunity for researchers to develop and test safe treatments for AMKD. Also speak with family members about having genetic testing done if you have the mutation as they may also have it.
Learn more and find additional resources at kidneyfund.org/APOL1aware.
Photo courtesy of Shutterstock
SOURCE:
American Kidney Fund
(Family Features) If your home uses a conventional heating and cooling system, you may wonder if there’s a better way to manage indoor comfort. Between rising energy costs and concerns about the efficiency of conventional systems, many homeowners are exploring alternatives. One popular solution is an all-climate heat pump.
All-climate heat pumps are the next generation of heat pump technology built for peak performance, regardless of the outdoor temperature. From the personalized comfort all-climate heat pumps deliver to the energy savings realized, it’s no wonder more homeowners are considering going all-in on all-climate.
If you’re considering replacing your current HVAC system, read on for some of the benefits of all-climate heat pumps.
Personalized Comfort
Ductless, multi-zone, all-climate heat pump systems are designed to deliver personalized, room-to-room temperature control tailored to your preferences. Unlike traditional ducted unitary systems, which typically operate on an all-or-nothing basis, ductless multi-zone solutions provide individualized climate settings for each space. Whether you prefer a warmer living room or a cooler bedroom, the flexibility to adjust each zone offers unparalleled convenience and energy efficiency.
Efficiency
According to a survey of U.S. homeowners commissioned by Mitsubishi Electric Trane HVAC US (METUS), 93% of homeowners surveyed with conventional HVAC systems reported concerns about utility bills. Seventy-five percent of those surveyed also consider energy efficiency always or often when considering home improvements.
Conventional heating and cooling systems run at full capacity to reach set point and then shut off. The start-stop action ultimately wastes energy. With variable-capacity capabilities and inverter-driven technology, all-climate heat pumps can adjust and maintain temperatures, lessening your home’s overall energy demand and driving down cost.
Cost Savings
The cost savings provided by efficient energy usage are evident. Additionally, some states offer rebates for new HVAC systems, and many contractors offer financing options, which make the upfront cost of an all-climate heat pump installation more affordable.
Reliability is another cost-saving factor. All-climate heat pumps are purpose-built with durable materials to perform well in all kinds of weather.
“We continue to educate homeowners about the advantages all-climate heat pumps have over conventional HVAC systems,” said Mark Kuntz, Chief Executive Officer, METUS. “As homeowners become more knowledgeable about the numerous benefits, including personalized comfort, energy efficiency and cost savings, we believe they will increasingly install these next-generation systems in their homes.”
Learn more about how you can better manage your home’s indoor comfort with all-climate heat pump technology by visiting mitsubishicomfort.com.
SOURCE:
Mitsubishi Electric
(Family Features) Like humans, pets’ oral hygiene plays an important role in their overall health and quality of life. Common conditions like plaque buildup, tartar and bad breath can escalate to serious health conditions if untreated.
In fact, by the age of 3, 80% of pets experience some form of dental health issue, and the risk only increases as they age. However, for many pet owners, taking care of their four-legged friends’ oral health is a more difficult habit to maintain than their own daily brushing and flossing routine.
Many veterinarians recommend regular brushing for pets, and a wide array of treats and meal additives complement brushing to help support your pet’s oral health.
Protecting your pet’s oral health begins by talking with your veterinarian, who can provide recommendations tailored to your pet’s specific needs. With that guidance, you can start comparison shopping and reading labels so you can identify quality products. Remember you’re likely to find the greatest success by introducing oral health products as part of your pet’s daily routine early on.
Certifications for Trust and Quality
awarded to products that meet strict standards for controlling plaque and tartar. You can find the seal on packaging as an easy visual indication of the product’s quality standards.
Natural, Effective Ingredients
Look for products that prioritize safety and health by offering natural, clinically proven ingredients and no artificial additives or chemicals. Seaweed (or kelp) is a preferred ingredient because it contains minerals and enzymes that help reduce plaque and prevent bacteria.
You can find 100% natural and organic kelp in products like ProDen PlaqueOff®, which includes A.N ProDen®, a kelp ingredient sustainably harvested from specially selected locations in the pristine North Atlantic waters off the Scandinavian coastline. Processed through a specialized method in extreme environmental conditions, it attains peak quality and effectiveness, ensuring safety and health for your pet.
Sustainable Practices
Another detail you can gather from the product’s packaging is whether a product manufacturer adheres to environmentally friendly practices and safe ingredient sourcing, which means the product is not only good for pets but also for the planet. This may be evident in certifications or special icons on the packaging, through information about sustainably harvested ingredients or with packaging that itself is environmentally responsible.
Tailoring to Individual Pets
Different pets have different needs based on age, size, breed and oral health status. Selecting the right product may also be complicated by your pet’s allergies or picky eating habits. You can find a variety of ingestible options, including powders, chews or bones like those offered by ProDen PlaqueOff®, to use in conjunction with daily brushing.
- Powder: Ideal for a seamless addition to your pet’s diet, this is the most economical choice, particularly for long-term use. It’s especially suitable for younger pets as a preventive measure, given its longevity and cost-effectiveness.
- Chews: For those looking for an easy-to-administer option that doubles as a reward, chews are the way to go. Additionally, for older pets or those with missing teeth, soft chews can offer a gentle yet effective way to maintain oral health. They’re a convenient choice for pet owners to give as a daily dose without the need for measuring or mixing.
- Bones: Designed not only to satisfy your dog’s natural chewing instincts but also to aid in dental care, bones are a perfect option for pet parents whose dogs prefer a longer-lasting treat. Bones come in a variety of flavors and sizes, catering to both large and small breeds, making them a versatile way to help keep your dog’s teeth clean and their breath fresh.
Learn more about protecting your pet’s dental health at us.swedencare.com.
Photo courtesy of Shutterstock (veterinarian examining dog)
SOURCE:
Swedencare
(Family Features) Here’s the secret for achieving a glowing complexion: there is no secret. In fact, a key factor in achieving great skin at any age comes down to one common denominator that’s no secret at all. It’s simply taking good care of your skin.
After all, your skin is your body’s single largest organ. It’s your protective shield, but it can also reveal the truth of your age, especially if you’re lax when it comes to regular skin care.
Make hydration a priority. Keeping the skin hydrated maintains its barrier integrity. When the skin becomes dry, it reduces the effectiveness of the skin barrier, making it less resilient against irritants and allergens.
Often, when the skin is dry it feels more rough or flaky. With proper hydration, the skin feels smoother and looks more supple. Achieving hydration through a better skin care routine, drinking plenty of water daily and eating certain fruits and vegetables can improve your skin’s appearance, maintaining a radiant, healthy complexion.
Use the right soap. Despite what your mother may have told you, squeaky clean isn’t always best. A better bet when it comes to soap is a product that respects your skin’s moisture balance and cleanses without creating tightness or irritation.
Mild options such as Pears skin cleansing products are specifically formulated and dermatologically tested to be gentle on the skin. They’re made with plant-based glycerin, which is a powerful humectant that attracts water from the environment and deeper layers of the skin to the outer layer, keeping it hydrated. Glycerin-based cleansers can help prevent stripping of the skin’s natural oils, which averts a tight, dry feeling.
“More than ever, consumers are looking for mild and gentle products that are effective, smell good and work well,” said Dr. Adriana Lombardi, founder of the Skin Cancer & Cosmetic Surgery Center of New Jersey. “Pears soap checks all the boxes. It creates a really nice, thick lather and smells crisp and clean while leaving the skin hydrated.”
Avoid hot showers. Even the best products may not overcome the potential harm that comes from taking showers that are too hot. The heat removes your skin’s natural oils, which leaves you prone to itching and dryness and may worsen skin conditions.
Instead of cranking up the heat, opt for lukewarm temperatures and keep the shower time brief. Use moisturizing cleansers, and after your shower, immediately apply moisturizer to replenish and rehydrate your skin.
Protect your skin from the sun. After completing your skin cleansing routine, there’s an additional step to help maintain healthy, hydrated skin before heading outdoors: Take time to apply a layer of sunscreen to skin that will be exposed, including your face, ears and hands. Reapply every two hours if you’re spending a great deal of time outside. Sun damage can prematurely age the skin. You may not feel the heat as much during colder times of year, but the rays are still capable of damaging your skin, maybe even more so because you don’t feel the burn
Find more advice for keeping your skin supple and soft at Amazon.com/pears.
3 Steps to Practice a Healthy Skin Routine
- Use a humidifier in your room. Adding moisture to your environment may help prevent over-drying and promote better air quality for your overall health, including your skin.
- Use glycerin-based soap. A glycerin-based soap like Pears gently cleanses your skin without stripping essential moisture.
- Moisturize immediately after showering. Showering, especially at higher water temperatures, can strip your body’s natural oils. Applying lotion immediately after you shower helps retain the moisture your body nee
Photos courtesy of Shutterstock (woman applying moisturizer, man applying moisturizer)
SOURCE:
Pears
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