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HEALTHY LIVING

Making Alzheimer’s just a memory

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An in-depth look at Alzheimer’s and work to find a cure

(Family Features) Although the COVID-19 pandemic turned the world upside down, the rapid development of multiple vaccines has spurred hope that treatments – or even potential cures – may be found for other devastating conditions. One such candidate is Alzheimer’s Disease.

Understanding Alzheimer’s

The Alzheimer’s Association defines the disease as a type of dementia that affects memory, thinking and behavior. While some degree of memory loss is common with age, Alzheimer’s symptoms are significant enough to affect a person’s daily life and typically only grow worse over time.

Early signs of Alzheimer’s include trouble remembering new information, solving problems or completing familiar tasks. As the disease progresses, disorientation, confusion, significant memory loss and changes in mood or behavior may become apparent. Physical symptoms may include difficulty speaking, swallowing or walking.

Impact of Alzheimer’s

Among people aged 65 and older, 1 in 9 (11.3%) has been diagnosed with Alzheimer’s Disease, meaning more than 6 million Americans live with it. Worldwide, the World Health Organization estimates there are nearly 50 million people living with dementia, and Alzheimer’s likely accounts for 60-70% of those. By 2050, this number could rise as high as 13 million. Less commonly noted are the numbers of early-onset (under 65 years old) Alzheimer’s patients within those figures. Up to 9% of global Alzheimer’s cases are believed to be early onset, according to the World Health Organization.

According to a Harvard School of Public Health survey, Alzheimer’s is second only to cancer among America’s most feared diseases. However, data from the Alzheimer’s Association shows Alzheimer’s is the sixth-leading cause of death in the United States, a rate higher than breast cancer and prostate cancer combined.

Beyond the personal impact for those battling the disease and their loved ones, Alzheimer’s Disease also takes a significant economic toll. The Alzheimer’s Association predicts that in 2021, Alzheimer’s and other dementias will cost the nation $355 billion. By 2050, these costs could exceed $1 trillion if no permanent treatment or cure for Alzheimer’s is found. At the same time, more than 11 million Americans provide unpaid care for people with Alzheimer’s and other dementias, an estimated 15.3 billion hours of care, valued at nearly $257 billion.

Milton Todd Ault III, founder of Alzamend Neuro

Treatment Options

While there hasn’t been enough significant progress in discovering a treatment or cure in the more than 100 years since Alzheimer’s was first identified in 1906, early diagnosis and treatment may improve the quality of life for patients. The disease affects each patient differently, so therapies vary widely depending on how far it has progressed and which symptoms are most prevalent. Some therapeutic approaches can address symptoms like sleep disruption and behavior while medication may be beneficial for treating other symptoms.

Founded in 2016 by Milton “Todd” Ault III, Alzamend Neuro, a preclinical-stage biopharmaceutical company, has been actively seeking a cure for Alzheimer’s and concentrates on researching and funding novel products for the treatment of neurodegenerative diseases and psychiatric disorders. With two products currently in development, the company aims to bring these potential therapies to market at a reasonable cost as quickly as possible.

Ault’s stepfather is currently battling Alzheimer’s, his mother-in-law died from the disease and he has three other family members suffering through it.

“Even though work has been done to find a cure for Alzheimer’s, to me it hasn’t been a full-court press,” said Ault, whose many personal encounters with Alzheimer’s have further fueled his passion to find a cure. “While there are no profound treatments today for Alzheimer’s disease, we believe we can change that.”

Practical Ways to Fast-Track a Cure

Some basic changes in the approach to disease research could accelerate progress for diseases like Alzheimer’s, said Milton “Todd” Ault III, founder of Alzamend Neuro.
Ault believes recent advancements in vaccines and medical technology, combined with these five approaches, can help advance the search for a cure for Alzheimer’s disease and other dementias.

Encourage public-private partnerships

The collaboration of government agencies and private industries was integral to the COVID-19 vaccine development. The cross-industry partnerships enabled a vaccine to get to market in less than one year despite detractors. Ault believes this model can be replicated for other diseases and conditions.

Diversify the search

Because of its complexity, a cure for Alzheimer’s will require expertise from a broad range of organizations including health and defense, biopharmaceutical firms, academic experts and those involved in Operation Warp Speed, the federal effort that supported multiple COVID-19 vaccine candidates simultaneously to expedite development.

Share standards and data

Focusing on a shared goal is vital to succeeding. This means looking for ways to share standards and collaborate with colleagues and competitors regardless of proprietary data, patents and other limitations.

Become the catalyst for a cure

When political will and government funding are insufficient or unable to drive change, the private sector can inspire action.

“The progress we are making is a result of the private investment dollars we secured and the way we have applied strategy and tenacity that comes from a successful business record,” Ault said.

Learning from past successes

Aside from the result, there is a great deal to learn from the successful development of past drugs and vaccines. Social awareness and cultural demand are potential ways to stimulate faster production and approvals between public and private entities.

To learn more about treatments and therapies in development visit alzamend.com .

Photo courtesy of Getty Images (Father and daughter)

SOURCE:
Alzamend Neuro

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Breathe better with asthma, wherever you are

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(Family Features) If you have asthma, you know that symptoms can come on quickly, then worsen.

The things that make them do that are called triggers. An important part of managing asthma is knowing your triggers at home, work, school or while you’re outdoors.

A health care provider can help you figure that out, then you can take steps to avoid those triggers and breathe easier.

At Home
Because asthma is usually due to allergies, triggers are often allergens, or things that cause allergic reactions. Allergens such as pet dander, dust mites, pests and smoke can make asthma symptoms worse in some people, and for others, even trigger an asthma attack.  

The National Heart, Lung, and Blood Institute (NHLBI) suggests that it may be helpful to combine a few different strategies to help reduce exposure to triggers.

People sensitive to dust can clean with a high-efficiency particulate air (HEPA) filtration vacuum and use mattress and pillow covers that prevent exposure to dust mites. If you’re sensitive to pests like cockroaches and rodents, consider integrated pest management, which involves removing and controlling pests through methods such as traps or poison. Avoiding tobacco smoke, including secondhand smoke, can be especially helpful for some people with asthma.

At School
Asthma is one of the leading reasons children miss school. At school, kids may be exposed to dust mites, pests and mold, which may be asthma triggers for some children.

Because children spend lots of time at school, it can be helpful for teachers, school nurses or coaches to know what to do if your child’s symptoms flare up. Team up with a health care provider to develop an asthma action plan and share it with trusted adults at your child’s school.

At Work
The workplace can have hundreds of potential triggers, like chlorine-based cleaning products, bleaches, hair dyes and metal dust. Repeated exposures in the workplace can also lead to new triggers. Report new or worsening symptoms that occur at work to your health care provider and your workplace supervisor.

Outdoors
Everyday weather like cold, dry air can set off breathing problems. Air pollution can affect asthma, too.

It may be helpful to avoid some of the worst pollution by adjusting when and where you exercise. Try to avoid exercising near busy roads or industrial areas. Visit airnow.gov to check your local air quality so you can plan to avoid outdoor activities when pollution is highest.

Managing your triggers is just one part of keeping your asthma under control. Work with a health care provider to develop an asthma treatment plan that includes taking medicines as prescribed and keeping track of your symptoms and where you are when they occur. That way, you can know what’s making your asthma worse or better.

To learn more about asthma, visit NHLBI’s Learn More Breathe Better® program at nhlbi.nih.gov/BreatheBetter.

Photo courtesy of Shutterstock


SOURCE:
National Heart, Lung, and Blood Institute

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Walk your way to better health

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(Family Features) A walk is not just good for your body, it’s also good for your soul. Physical activity, like walking, is one of the best ways to reduce stress and boost your mood. However, reports show walking rates are declining steadily in the United States.

On average, 1 out of every 4 U.S. adults sits for longer than eight hours each day, per research from the Centers of Disease Control and Prevention, which can have negative consequences on physical and mental health. Regular exercise improves mood, boosts energy and can even help you sleep better. Staying active is one of the best ways to keep your mind and body healthy.

Consider this advice from the American Heart Association, which has worked for decades to promote policies and strategies that make it easier for communities to get and stay active. One example is National Walking Day on April 3, established by the organization to encourage people to move more throughout the day so they can feel, think, sleep and live better.

Indeed, adding more movement can benefit your body and mind in numerous ways, such as:

Lowering disease risk. Getting the recommended amount of physical activity (at least 150 minutes of moderate, 75 minutes of vigorous or a combination of those activities per week) is linked to lower risk of diseases, stronger bones and muscles, improved mental health and cognitive function and lower risk of depression, according to the U.S Department of Health and Human Services.

Increasing sunlight exposure. Outdoor exercise is an easy way to get moving and take in the sunlight, which can improve mood, boost immunity and help you get some vitamin D. Spending time outdoors is a no-cost option and has been shown to reduce stress, promote a sense of belonging and improve mood.

Improving cognitive and mental function. Physical activity keeps your mind sharp now and later. Studies show higher fitness levels are linked to better attention, learning, working memory and problem solving. What’s more, a study published in the “British Journal of Sports Medicine” shows people who get the recommended amount of physical activity are less likely to develop depression.

Living longer. Healthy life expectancy can be positively impacted by increasing activity. According to research published in the “American Journal of Epidemiology,” swapping just 30 minutes of sitting with low-intensity physical activity reduced risk of death by 17%.

Get moving to reduce your stress and step into better health. Learn more at heart.org/movemore.

Get Inspired to Get Moving

A little creativity can go a long way to make your walk more fun. You might think of walking as a solo activity, but a companion makes it even more enjoyable. Ask colleagues, friends or family to join you.

A walk is a perfect excuse to take a break from a long day at your desk. If you work remotely, take a conference call on the go or plan your walk as a reward for completing a project.

Use your walk as a guilt-free opportunity to listen to a new audiobook or create a walking soundtrack of your favorite upbeat music.

Mix up your scenery. Taking new routes keeps your walks interesting and helps prevent boredom from traveling the same predictable path.

If you need an extra nudge to get moving, a pet may help you get fit. Dog parents are more likely to reach their fitness goals than those without canine companions. In fact, according to the “Journal of Physical Activity & Health,” dog parents are 34% more likely to fit in 150 minutes of walking a week than non-dog owners. Pets can also help lower stress, blood pressure, cholesterol and blood sugar and boost your overall happiness and well-being.

Photos courtesy of Shutterstock


SOURCE:
American Heart Association

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A genetic connection to kidney disease

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How APOL1-mediated kidney disease can impact you, your kidneys and your family

(Family Features) A genetic condition that can cause kidney failure, APOL1-mediated kidney disease (AMKD) represents a group of kidney diseases associated with mutations (changes or variants) in the apolipoprotein L1 (APOL1) genes.

Typically, the APOL1 genes – of which every person has two, one from each parent – create proteins that play a role in immunity. However, some people are born with mutations in one or both genes, and having mutations in both can increase the risk of developing kidney disease and even kidney failure.

In honor of National AMKD Awareness Day on April 30, consider this information from the experts at the American Kidney Fund to better understand the disease and become APOL1 aware.

Understanding Risk Factors
Research shows Black people with kidney disease are more likely to develop kidney failure than any other racial or ethnic group. The reasons for these health disparities include social determinants of health, a higher burden of diabetes and high blood pressure in the Black community, barriers to health care access and genetics.

The APOL1 gene mutations evolved over the past 3,000-10,000 years in people who lived in western and central Africa and are associated with increased protection from a parasite carried by the tse tse fly that causes African sleeping sickness. While protecting from one disease, the mutation – if inherited in both APOL1 genes – is more likely to lead to kidney disease in those of certain African descent, including people who identify as Black, African American, Afro-Caribbean or Latina or Latino.

In fact, an estimated 13% of Black Americans have two APOL1 gene mutations, according to the American Kidney Fund. While not everyone who has two APOL1 mutations will get kidney disease, there is a 1 in 5 chance they will go on to develop AMKD.

Identifying Symptoms
If you have kidney damage, symptoms may not occur until your kidneys are close to failing. As kidney damage worsens, one or more of these symptoms may occur:

  • Protein in urine
  • Swelling in legs or weight gain
  • Feeling weak or tired
  • High blood pressure

Should these symptoms occur and you have a family history of kidney disease, talk to a doctor about getting tested for kidney disease, as testing is the only way to determine kidney function. AMKD can cause damage to parts of the kidney that filter blood or, in some cases, cause cells in the kidneys to die, which can lead to damage and scarring that may eventually lead to kidney failure.

Getting a Diagnosis
The only way to know if you have APOL1 gene mutations is to do genetic testing via a blood or saliva sample. Genetic testing may be considered if you have kidney disease and don’t know the cause or if you’re considering donating a kidney. Testing may also be considered if a family member is a carrier for the mutation. If you have questions about genetic testing, discuss your options with a doctor or ask for a referral to a genetic counselor.

Taking Steps to Prevent Kidney Disease
There are currently no treatments available for AMKD. However, there are steps you can take to protect your kidneys and promote general health. Work with your doctor to create a plan to prevent or delay the progression of kidney disease, which may include:

  • Doctor visits to check how your kidneys are working through urine and blood tests
  • Checking for and managing diabetes and high blood pressure
  • A healthy eating plan, which may involve limiting things like sodium (salt)
  • Taking prescription medications as directed
  • Being active at least 30 minutes each day of the week
  • Quitting smoking or using tobacco

If you have the APOL1 gene mutations, you may be able to take part in clinical trials. Trials could provide an opportunity for researchers to develop and test safe treatments for AMKD. Also speak with family members about having genetic testing done if you have the mutation as they may also have it.

Learn more and find additional resources at kidneyfund.org/APOL1aware.

Photo courtesy of Shutterstock


SOURCE:
American Kidney Fund

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