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Reaching your personal goals with a chronic illness

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(BPT) – Content sponsored and provided by Pfizer.

Janet H., a wife and mother from Alabama, had many things to celebrate in her life – two beautiful children, a wonderful husband, her dog Falco, and a rewarding career. She was proud that even with all of this, she was able to achieve her personal goal of staying active. However, she was diagnosed with a chronic disease the week before her 40th birthday.

Janet enjoyed moderate exercise, so when she began to have persistent joint pain and swelling in her knees, she suspected it was from an old injury. After initial visits with an orthopedic specialist, she was referred to a rheumatologist who diagnosed her with moderate to severe rheumatoid arthritis (RA) – a chronic, autoimmune disease of the joints.[i]

“I remember thinking that if this is what 40 is like, I don’t know if I can handle 50,” she says. “I wasn’t sure how RA would affect my life.”

Unfortunately, this story is all too common, as RA impacts approximately 1.6 million adults in the United States.[ii],[iii] Many living with a chronic condition like RA can feel that their life is put on hold while trying to manage their symptoms, doctor’s appointments, and the daily demands of life. Working toward personal goals can be put on the backburner, but does it have to be?

With her rheumatologist, Janet was motivated to find a treatment plan that could help relieve her RA symptoms before being prescribed XELJANZ® (tofacitinib) 5 mg twice daily tablets, an oral medication for adults with moderate to severe RA in which methotrexate did not work well enough. Janet’s rheumatologist reviewed the potential side effects of XELJANZ and explained that it is taken twice daily and has a BOXED WARNING for serious infections and malignancies.

Within three to six months, Janet felt improvement in her RA symptoms and found herself thinking about ways to become more active. She spoke with her rheumatologist and, together, they came up with exercise goals including yoga classes, cycling, and walking her dog with her husband and children. She also says one of her biggest milestones was walking her daughter down the aisle and gaining a new son-in-law. Eventually, Janet even worked with her rheumatologist to switch to a once-a-day version of XELJANZ, called XELJANZ XR extended release tablets.

Here are some of Janet’s tips to help someone living with a chronic illness work toward their personal goals:

Plan ahead: Living with a chronic condition can put a pause on spontaneity. Plan ahead when it comes to things like travel or big life events to allow ample time for adjustments and preparation.

Partner up: Find a significant other, friend or sibling who can join you on your journey toward reaching your goals. Sometimes living with a chronic condition requires extra support from others, so having a partner to plan with can help make that support seamless

Consult your doctor: Before considering any new travel or physical activity, make sure to consult your doctor. Discuss your plans and how you and your doctor can work together to help ensure you can meet these goals.By following these tips, Janet says that she has been able to better manage her RA and have more time to focus on her family, friends and herself.

“I hope my story can help other adults who are living with moderate to severe rheumatoid arthritis and inspire them to share their stories,” she says.

What is XELJANZ/XELJANZ XR?

XELJANZ/XELJANZ XR is a prescription medicine called a Janus kinase (JAK) inhibitor. XELJANZ/XELJANZ XR is used to treat adults with moderately to severely active rheumatoid arthritis in which methotrexate did not work well.

It is not known if XELJANZ/XELJANZ XR is safe and effective in people with hepatitis B or C.

XELJANZ/XELJANZ XR is not recommended for people with severe liver problems.

It is not known if XELJANZ/XELJANZ XR is safe and effective in children.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about XELJANZ/XELJANZ XR?

XELJANZ/XELJANZ XR may cause serious side effects, including:

Serious infections. XELJANZ/XELJANZ XR can lower the ability of your immune system to fight infections. Some people can have serious infections while taking XELJANZ/XELJANZ XR, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections. Your healthcare provider should test you for TB before starting and during XELJANZ/XELJANZ XR treatment, and monitor you closely for signs and symptoms of TB infection during treatment. You should not start taking XELJANZ/XELJANZ XR if you have any kind of infection unless your healthcare provider tells you it is okay.

You may be at a higher risk of developing shingles (herpes zoster).

Before starting XELJANZ/XELJANZ XR, tell your healthcare provider if you:

think you have an infection or have symptoms of an infection, such as fever, sweating, or chills; cough; blood in phlegm; warm, red, or painful skin or sores on your body; burning when you urinate or urinating more often than normal; muscle aches; shortness of breath; weight loss; diarrhea or stomach pain; or feeling very tiredare being treated for an infectionget a lot of infections or have infections that keep coming backhave diabetes, chronic lung disease, HIV, or a weak immune system. People with these conditions have a higher chance for infectionshave TB, or have been in close contact with someone with TBlive or have lived in, or have traveled to certain parts of the country (such as the Ohio and Mississippi River valleys and the Southwest) where there is an increased chance for getting certain kinds of fungal infections (histoplasmosis, coccidioidomycosis, or blastomycosis). These infections may happen or become more severe if you use XELJANZ/XELJANZ XR. Ask your healthcare provider if you do not know if you have lived in an area where these infections are commonhave or have had hepatitis B or CAfter starting XELJANZ/XELJANZ XR, call your healthcare provider right away if you have any symptoms of an infection. XELJANZ/XELJANZ XR can make you more likely to get infections or make worse any infection that you have.

Cancer and immune system problems. XELJANZ/XELJANZ XR may increase your risk of certain cancers by changing the way your immune system works. Lymphoma and other cancers, including skin cancers, have happened in patients taking XELJANZ/XELJANZ XR. Tell your healthcare provider if you have ever had any type of cancer.

Some people who have taken XELJANZ with certain other medicines to prevent kidney transplant rejection have had a problem with certain white blood cells growing out of control (Epstein Barr Virus-associated post-transplant lymphoproliferative disorder).

Tears (perforation) in the stomach or intestines. Some people taking XELJANZ/XELJANZ XR can get tears in their stomach or intestine. This happens most often in people who also take nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or methotrexate.

Tell your healthcare provider right away if you have fever and stomach-area pain that does not go away and a change in your bowel habits.

Changes in certain lab test results. Your healthcare provider should do blood tests before you start receiving XELJANZ/XELJANZ XR, and while you take XELJANZ/XELJANZ XR, to check for the following side effects:

changes in lymphocyte counts. Lymphocytes are white blood cells that help the body fight off infections.low neutrophil counts. Neutrophils are white blood cells that help the body fight off infections.low red blood cell count. This may mean that you have anemia, which may make you feel weak and tired.Your healthcare provider should routinely check certain liver tests.

You should not receive XELJANZ/XELJANZ XR if your lymphocyte count, neutrophil count, or red blood cell count is too low or your liver tests are too high. Your healthcare provider may stop your XELJANZ/XELJANZ XR treatment for a period of time if needed because of changes in these blood test results.

Your healthcare provider should do blood tests to check your cholesterol levels 4-8 weeks after you start XELJANZ/XELJANZ XR, and as needed after that.

What should I tell my healthcare provider before taking XELJANZ/XELJANZ XR?

Before taking XELJANZ/XELJANZ XR, tell your healthcare provider about all of your medical conditions, including if you:

have an infectionhave liver problemshave kidney problemshave any stomach area (abdominal) pain or been diagnosed with diverticulitis (inflammation in parts of the large intestine) or ulcers in your stomach or intestines, or narrowing within your digestive tracthave had a reaction to tofacitinib or any of the ingredients in XELJANZ/XELJANZ XRhave recently received or are scheduled to receive a vaccine. People taking XELJANZ/XELJANZ XR should not receive live vaccines but can receive non-live vaccinesplan to become pregnant or are pregnant. It is not known if XELJANZ/XELJANZ XR will harm an unborn baby. You should use effective birth control while you are taking XELJANZ/XELJANZ XR and for at least 4 weeks after you take your last dose.Pregnancy Registry: Pfizer has a registry for pregnant women who take XELJANZ/XELJANZ XR. The purpose of this registry is to check the health of the pregnant mother and her baby. If you are pregnant or become pregnant while taking XELJANZ/XELJANZ XR, talk to your healthcare provider about how you can join this pregnancy registry or you may contact the registry at 1-877-311-8972 to enrollplan to breastfeed or are breastfeedingTell your healthcare provider about all of the medicines you take, especially any other medicines to treat your rheumatoid arthritis. You should not take tocilizumab (Actemra®), etanercept (Enbrel®), adalimumab (Humira®), infliximab (Remicade®), rituximab (Rituxan®), abatacept (Orencia®), anakinra (Kineret®), certolizumab pegol (Cimzia®), golimumab (Simponi®), ustekinumab (Stelara®), secukinumab (Cosentyx®), azathioprine, cyclosporine, or other immunosuppressive drugs while you are taking XELJANZ/XELJANZ XR. Taking XELJANZ or XELJANZ XR with these medicines may increase your risk of infection.

Tell your healthcare provider if you are taking medicines that affect the way certain liver enzymes work. Ask your healthcare provider if you are not sure if your medicine is one of these.Taking XELJANZ/XELJANZ XR

When you take XELJANZ XR, you may see something in your stool that looks like a tablet. This is the empty shell from the tablet after the medicine has been absorbed by your body.

What are other possible side effects of XELJANZ/XELJANZ XR?

XELJANZ/XELJANZ XR may cause serious side effects, including hepatitis B or C activation infection in people who carry the virus in their blood. If you are a carrier of the hepatitis B or C virus (viruses that affect the liver), the virus may become active while you use XELJANZ/XELJANZ XR. Tell your healthcare provider if you have the following symptoms of a possible hepatitis B or C infection: feel very tired, little or no appetite, clay-colored bowel movements, chills, muscle aches, skin rash, skin or eyes look yellow, vomiting, fevers, stomach discomfort, or dark urine.

Common side effects of XELJANZ/XELJANZ XR include upper respiratory tract infections (common cold, sinus infections), headache, diarrhea, and nasal congestion, sore throat, and runny nose (nasopharyngitis).

To learn more about XELJANZ/XELJANZ XR, a treatment option for moderately to severely active RA, visit XELJANZ.com.

Please click the direct link to the full US Prescribing Information for XELJANZ/XELJANZ XR, including BOXED WARNING and Medication Guide: http://labeling.pfizer.com/ShowLabeling.aspx?id=959.

[i] National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). National Institutes of Health, Department of Health and Human Services. Handout on health: rheumatoid arthritis. August 2014. http://www.niams.nih.gov/Health_Info/Rheumatic_Disease/default.asp. Accessed December 4, 2017.

[ii] Sacks J, Lou Y, Helmick, C. Prevalence of specific types of arthritis and other rheumatic conditions in the ambulatory health care system in the United States 2001-2005. Arthritis Care Res. 2010;62(4):460-464.

[iii] Howden L, Meyer J. 2010 U.S. Census Bureau results – U.S. Census Bureau, 2010 Census Summary File 1.

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Alleviating the burden in treating type 1 diabetes, chronic kidney disease

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(Family Features) While diabetes gets a lot of attention, people with Type 1 Diabetes (T1D) are frequently overlooked when drug companies develop new medications.

“People with T1D and chronic kidney disease, or CKD, face significantly higher risks of morbidity and mortality if they are unable to control their blood sugar levels,” said Steve Edelman, MD, an endocrinologist and the founder and director of Taking Control Of Your Diabetes, a not-for-profit organization dedicated to educating and motivating people living with diabetes. “They are challenged to do this relying solely on insulin, which is extremely difficult and is the principal therapy for people with T1D.”

An estimated 1.7 million adult Americans have T1D, with approximately 21%, or 360,000, also affected by CKD, according to the CDC National Diabetes Statistics Report 2024. Without effective glycemic control (managing blood sugar) and other important preventative measures, patients with T1D are at a 10 times higher risk of cardiovascular disease, a six-fold greater risk of progression to end-stage kidney disease, a four times greater risk of heart failure and a 2-5 times greater risk of all-cause mortality.

Consider this information to better understand the challenges and risks of complications these patients face.

Challenges with Current Treatments Impact Patients’ Ability to Reach Glycemic Goals
Diabetes management aims to reduce the risks of cardiovascular disease, kidney failure, retinopathy, neuropathy and other complications, in part by improving glycemic control while minimizing the risk of hypoglycemia.

Currently, Americans with T1D have limited therapeutic options, relying almost exclusively on insulin. There are no oral agents to improve glycemia in adults with T1D. Despite advances in insulin therapy and glucose monitoring, most people with T1D do not meet glycemic control target levels with insulin alone. One measure of glycemic control is a number known as A1C, which is a measure of glucose control over the past 2-3 months.

The goal is to help patients achieve the guideline-recommended target of an A1C below 7% and improve their time-in-range, which represents an established metric that translates into clinically meaningful benefits for patients.

Reaching Glycemic Goals Are Key to Reducing Risk of Further Complications
By achieving glycemic control, kidney function can be stabilized, long-term disease progression mitigated and the morbidity and mortality that the cardiorenal burden puts on patients with T1D and CKD reduced.

Today, it is estimated only 23% of people with T1D achieve an A1C of less than 7%, according to research from the American Diabetes Association, and about 50% have an A1C greater than 8%. Patients who do not achieve A1C targets remain at significantly greater risk of complications associated with their condition.

“Relying solely on insulin can negatively affect a patient’s glucose control and quality of life,” said Dr. Edelman. “Doctors and patients need an oral agent to improve glycemic control in people with T1D and CKD. Therefore, we need therapeutic options that improve glycemic control and reduce their risk of kidney disease progression and cardiovascular comorbidities.”

Visit TCOYD.org to learn more about living with T1D and advocating for additional therapeutic options.

Photos courtesy of Getty Images


SOURCE:
Taking Care of Your Diabetes

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Helpful hints for the holidays

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(Family Features) Gift-giving during the holiday season shouldn’t be stressful. In fact, finding gifts for your loved ones should be as much fun as giving (and receiving) them.

No matter if you’re shopping for the fashionista, the foodie, the workout warrior, the tech expert, the beauty-focused or nearly anyone else on your list, this helpful guide of gift ideas to match a variety of personalities and interests can make the holiday season extra special for both the giver and recipient.

Find more holiday gift-giving inspiration at eLivingtoday.com.

Give the Gift of Skin Nourishment

This holiday season, give your loved ones the gift of brighter, healthier-looking skin. Clinically formulated by experts and health care professionals for every skin care need, Medline Remedy products combine advanced skin care science with gentle, therapeutic ingredients. The proprietary Remedy Nutrient Complex nourishes, soothes and supports moisture balance while caring for even the most sensitive skin. Find the full product line from the No. 1 skin care brand in health care (according to Clarivate health care market data through December 2023) at Amazon.com and Walmart.com.

Power Productivity and Connection

Perfect for that special someone who’s always connected, fuel his or her productivity with Galaxy AI on the Samsung Galaxy Z Fold6 powered globally by Snapdragon 8 Gen 3. Enjoy multitasking on up to three windows using multi-active Window, speak with someone in another language with live translations you both can see and experience desktop-level gaming with ray tracing. Plus, your loved one can enjoy ultra-fast connectivity for all that chatting, social networking, gaming and more with Qualcomm FastConnect 7800. Find more information at Bestbuy.com.

Share Memories with Loved Ones

With sleek designs to fit nearly any decor, a digital picture frame is a thoughtful way to share and display a continuous slideshow of photos on a mantel, bookshelf or desk. Simply upload pictures via USB, SD card, Wi-Fi or a frame-specific app, and your loved one can relive special moments every day. Some models also offer video playback, calendar implementation and automatic cropping, brightness and power-saving functions, making them a multifunctional addition to any home or office space.

Provide Relief and Relaxation

Ideal for athletes, fitness enthusiasts or anyone with a physically demanding lifestyle, a handheld massage gun can help alleviate muscle tension, improve circulation and speed up recovery after workouts, making one an optimal gift for anyone on your list who could use a well-being boost. Easy to use, these compact devices use percussive therapy to target sore muscles and provide deep tissue massage by using various attachments and adjustable speed settings to target different muscle groups and customize the massage experience.

Take Tunes Anywhere You Go

Whether your loved ones enjoy outdoor adventures or relaxing at home, Bluetooth speakers are a perfect gift idea to enhance the listening experience no matter where they are. With a variety of sizes and styles available, you can find something that fits every music lover’s taste, from compact and portable options to larger, high-fidelity models for home use. Many speakers also include additional features like waterproofing, floatability, long battery life, power banks for external device charging and voice assistant integration.

Upgrade Beauty Essentials

Whether you’re shopping for a beauty novice or a seasoned pro, makeup can make for a quick and easy stocking stuffer. Consider a curated set that includes items like mascara, lipstick, brushes, eyeshadow palettes and other tools to complete their beauty routine. Opting for a limited-edition holiday collection can add a festive touch to your gift. For a more personalized approach, create a custom kit tailored to the recipient’s preferences to provide joy and confidence well beyond the holiday season.

Photos courtesy of Shutterstock (family opening gifts, picture frame, massage gun, speaker, makeup)


SOURCE:
Medline Remedy



Qualcomm

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5 ways to make extra cash around the house

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(Family Features) Making money from everyday items in your home may be easier than you think. With a growing number of companies simplifying the process, turning unused items into cash has never been simpler.

These companies are part of the circular economy, where you get to make money from your items and feel good about it at the same time. By reselling items you don’t use, you can give these items a second home or repurpose them into something that has practical applications.

For example, unused gold and precious metal jewelry can be given a second home to or repurposed for vital technology sectors like health care. This reduces the need for environmentally taxing mining operations and gives these valuable resources a second purpose.

Whether it’s clothing, jewelry or tech, consider these simple ways to make extra cash by selling items online.

Sell Used Clothing
Some newer platforms offer a less hands-on approach to selling used clothing online. Unlike popular online platforms that require you to take pictures or create listings for your items, look for outlets that allow you to simply package your items and send them out with an insured label. This makes selling clothing online a breeze and reduces the potential headaches of dealing with buyers directly and managing listings.

Sell Unworn Jewelry
For precious metals like gold jewelry or silver jewelry, selling directly to a trusted buyer can provide a fast, secure way to unlock their value. Consider AlloyMarket.com, a company featured in trusted outlets like Forbes, NBC and US News & World Report that offers a streamlined process with free, insured shipping and no hidden fees or commissions. Unlike platforms that require complex listings or charge extra fees, you keep 100% of the quoted price. On average, customers earn $1,700 or more for gold jewelry and other precious metal items, offering a straightforward, easy and rewarding way to sell unused valuables.

Sell Designer Bags
If you have any designer bags at home, look for platforms that let you sell handbags directly to them and provide upfront estimates before you ship your items. Some platforms provide free insured shipping and marketplaces where you can buy designer handbags at discounted prices.

Sell Books You’ve Already Read
While this likely won’t make you a fortune, selling used books is a simple way to make some extra cash and help preserve the environment. College students in particular can benefit from upfront estimates and free shipping or the ability to trade in used books for ones they’ll need next semester. Plus, some platforms also offer books for purchase at heavily discounted prices.

Sell Tech After Upgrading
If you upgraded phones recently or have a used phone just collecting dust, get an upfront estimate for your phone from a trusted site. Some buyers provide free shipping and, with upfront estimates, you know exactly what you will get for your used phone before sending it in.

Sell Old Furniture
Turn your unused furniture into cash by listing items like sofas, tables or chairs on local marketplaces or apps. Clear photos and detailed descriptions can help attract buyers nearby, saving you the hassle of shipping. Selling old furniture not only earns extra money but also helps reduce waste by giving items a second life.

To learn more about how you can get a free, no-obligation estimate for gold jewelry or other precious metal items, visit AlloyMarket.com.


SOURCE:
Alloy Market

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