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HEALTHY LIVING

How to talk to your doctor about statin intolerance

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(Family Features) If your doctor has concerns about your cholesterol levels, you may be familiar with statins. This is a class of medications that can help reduce your body’s cholesterol production, lowering your risk of heart attack or stroke.

However, up to 30% of adults in the United States have some degree of statin intolerance, according to research published in the “Journal of Clinical Lipidology.” Possible signs or symptoms of statin intolerance are muscle aches and cramps, fatigue, weakness, elevated liver enzymes and the onset of diabetes or impaired glucose tolerance.

As a result, nearly one-third of patients (29%) discontinue their statin within the first year, according to findings published in the “American Journal of Cardiology.” Unfortunately, patients with statin intolerance are at an increased risk of cardiovascular disease, including higher rates of coronary heart disease and recurrent heart attack.

Lowering Bad Cholesterol
A diagnosis of high cholesterol involves measuring low-density lipoprotein (LDL) cholesterol, which is commonly referred to as “bad” cholesterol because it leads to the accumulation of plaque in your arteries. Plaque reduces your blood flow, which can cause damage to your cardiovascular system.

Bloodwork is the best indicator of your cholesterol levels, since you may not experience any symptoms of high cholesterol until you already have damage and buildup in your arteries.

To help create your treatment plan, talk to your doctor about your medical history, including whether you’ve had a heart attack or any heart procedures, such as a stent placement or bypass surgery. You’ll also review current medications, recent lab results and notes on any symptoms you may be experiencing.

Your doctor is likely to recommend a series of steps to reduce your cholesterol. Some common recommendations include a healthy diet low in saturated and trans fats and high in fiber, especially fruits, vegetables and whole grains.

If you’re not already getting regular physical activity, your doctor will likely encourage you to get at least 30 minutes of exercise daily, find ways to include more movement in your everyday lifestyle and, if necessary, work toward shedding extra weight.

Lifestyle changes can help but may not make a big enough impact to reduce cholesterol to a recommended level. In those cases, doctors rely on cholesterol-lowering medications such as statins. Statins can be highly effective at reducing bad cholesterol, making them a powerful tool to reduce the risks associated with heart disease.

When Statins Are Intolerable or Aren’t Enough
For a variety of reasons, including intolerance to the medication, other health conditions or interactions with other medications, statins may not be the right choice for everyone.

“While statins remain the gold standard for cholesterol lowering, I often see patients who either can’t or won’t take a statin, as well as patients who require further LDL cholesterol reduction,” said Guy L. Mintz, Director of Cardiovascular Health & Lipidolology at Northwell Health System. “For those patients, I prescribe non-statin medications, such as NEXLETOL (an oral prescription medication with the cholesterol lowering agent bempedoic acid) and NEXLIZET (a combination of cholesterol-lowering medicines bempedoic acid and ezetimibe). I am comfortable using NEXLETOL and NEXLIZET, along with a healthy diet and exercise, to reduce LDL cholesterol in adults with high blood cholesterol levels and to reduce risk of heart events. Non-statins are another important therapeutic tool in our lipid lowering toolbox.”

To learn more visit Nexlizet.com.

Photo courtesy of Shutterstock

IMPORTANT SAFETY INFORMATION
What are NEXLIZET tablets and NEXLETOL tablets?

  • Along with a diet:
    • NEXLETOL is used, with other cholesterol-lowering medicines, or alone when use with other cholesterol-lowering medicines is not possible, to reduce low-density lipoprotein (LDL, or bad cholesterol) in adults with high blood cholesterol levels called primary hyperlipidemia, including a type of high blood cholesterol called heterozygous familial hypercholesterolemia (HeFH).
    • NEXLIZET is used, with or without other cholesterol-lowering medicines, to reduce low- density lipoprotein (LDL, or bad cholesterol) in adults with high blood cholesterol levels called primary hyperlipidemia, including a type of high cholesterol called heterozygous familial hypercholesterolemia (HeFH).
  • The bempedoic acid portion of NEXLIZET and NEXLETOL is used to lower the risk of heart attack and heart procedures like stent placement or bypass surgery, in adults who are unable to take recommended statin treatment (a cholesterol-lowering medicine), or are not taking a statin, who:
    • have known heart disease, or
    • are at high risk for heart disease but without known heart disease.

Do not take NEXLIZET if you are allergic to ezetimibe or bempedoic acid, or any ingredients in NEXLIZET or NEXLETOL. If you have any of the following signs and symptoms of a serious allergic reaction, call your healthcare provider or go to the nearest hospital emergency room:

  • swelling of your face, lips, mouth, or tongue
  • wheezing
  • severe itching
  • fast heartbeat or pounding in your chest
  • trouble breathing
  • skin rashes, redness, or swelling
  • dizziness or fainting

What should I tell my healthcare provider before taking NEXLIZET or NEXLETOL? Tell your healthcare provider if you:

  • have, or had, gout
  • have or had tendon problems
  • are pregnant or breastfeeding or may become pregnant or plan to breastfeed. It is not known if NEXLIZET or NEXLETOL passes into your breastmilk
  • have severe kidney or severe liver problems

Tell your healthcare provider about all the medicines you take, including prescription and over-the- counter medicines, vitamins and herbal supplements.
Especially tell your healthcare provider if you take or plan to take simvastatin or pravastatin, as taking either with bempedoic acid may increase your risk of developing muscle pain or weakness. If you take NEXLIZET, tell your doctor if you take cyclosporine, fibrates, or cholestyramine.

What is the most important safety information I should know about NEXLIZET and NEXLETOL? NEXLIZET and NEXLETOL can cause serious side effects, including:

  • increased levels of uric acid in the blood, which can lead to gout, a painful joint condition. Call your doctor if you have any of the following symptoms: severe foot pain especially in the toe joint, warm joints, swelling, tender joints or joint redness.
  • tendon rupture or injury. Tendon problems can happen in people who take bempedoic acid, one of the medicines in NEXLIZET or NEXLETOL. The risk of getting tendon problems while you take NEXLIZET or NEXLETOL is higher if you: are over 60 years of age, are taking steroids, are taking antibiotics called fluoroquinolones, have renal failure, or have had tendon problems in the past. Stop taking NEXLIZET or NEXLETOL immediately and get medical help if you experience signs of tendon rupture such as snap or pop in tendon area, bruising after an injury in a tendon area, or unable to move or put weight on the affected area.

The most common side effects in people with primary hyperlipidemia:

  • NEXLETOL includes symptoms of the common cold or flu-like symptoms, muscle spasms, back pain, stomach pain, bronchitis, pain in shoulder, legs, or arms, anemia and increased liver enzymes.
  • NEXLIZET includes symptoms of the common cold or flu-like symptoms, muscle spasms, back pain, stomach pain, bronchitis, pain in shoulder, legs, or arms, anemia, increased liver enzymes, diarrhea, joint pain, swelling of sinuses and fatigue.

The most common side effects of bempedoic acid, a component of NEXLIZET and NEXLETOL, in people with heart problems include kidney problems, anemia, increased liver enzymes, muscle spasms, and gallstones.

These are not all the possible side effects of NEXLIZET and NEXLETOL. For more information, ask your healthcare provider or pharmacist for more information.

Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


SOURCE:

Esperion

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HEALTHY LIVING

The power of sharing a table: Americans reviving ‘IRL’ experiences with drinks, dinner and beyond

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(Feature Impact) Real-world connection has become increasingly rare and if you’ve felt the effects, you’re not alone. After years of digital-first habits becoming the new norm, many people are looking to rediscover face-to-face social interaction – “IRL,” in real life, not from behind a screen.

With many Americans now spending less time together than ever before as in-person contact continues to decline, according to data from the Organization for Economic Co-operation and Development, Teremana Tequila is inviting people back to something simple: the table. Rooted in the philosophy of Mana – the brand’s guiding core philosophy and belief that good energy is contagious and the best moments in life happen when people come together – its “Share the Table, Share the Mana” initiative and partnership with Timeleft, a global app that matches strangers into small groups for real-life meetups, is a call for real-world connection.

A gradual rebalancing is underway, according to Teremana. In a world where people are more digitally connected yet more personally disconnected, sometimes all it takes is one small gesture, like pulling up a chair and sharing a table to unlock something transformative.

Activity-Based Communities

According to the American Psychiatric Association, 1 in 3 American adults went at least a week in 2024 without feeling genuinely connected. In response, many people are shifting toward connection rooted in shared activities rather than conversation alone. Consider Eventbrite’s 2026 Social Trends Report, which found 58% of people now prefer events where socializing isn’t the primary focus, signaling a growing appetite for in-person gatherings built around common interests and experiences.

Recurring events – such as weekly trivia nights or monthly potlucks – reflect this shift toward activity-based connection. With a built-in rhythm and shared interest, they reduce the pressure of constant planning and allow relationships to develop more naturally over time. Whether it’s a standing “taco Tuesday” or “trivia Thursday,” these gatherings create structure that makes it easier for people to simply show up and enjoy the moment together.

This shift is also extending beyond traditional community spaces into experiences that transform everyday environments into opportunities for connection.

Third Spaces, Reimagined

Building on its spirit of good energy and shared moments, Teremana Tequila’s “Share the Table, Share the Mana” campaign kicked off with a series of out-of-home billboards across the country, but took a surprising turn when what appeared to be a standard billboard concealed a hidden bartender, drinks and an open invitation to share the table – turning a street corner into an unplanned gathering space for strangers. More experiential moments like this are on the way.

While digital tools remain central to how people connect, they’re increasingly being used to facilitate in-person moments – helping organize meetups, dinners, and shared experiences in the real world.

For example, by partnering withTimeleft, a global app that matches strangers into small groups for real-life meetups, Teremana’s idea is becoming a nationwide movement. Every Thursday from now through August, the Share the Table series will bring curated groups of people together at bars and restaurants across 13 U.S. cities, creating a consistent space for the kind of unscripted human connection no screen can replicate.

The nationwide initiative offers a key to unlocking something much bigger than one-off moments as an investment in infrastructure for connection, providing strangers opportunities to match with groups of people with similar interests and compatibilities.

Neighborhoods as a Nexus for Connection

By meeting and greeting neighbors and attending local events, the reliance on digital tools can be reversed. Proximity lowers barriers like time and distance, increasing the likelihood of repeated encounters for after-work drinks or dinner parties that allow for relaxed, low-pressure socializing.

For an easy way to break the ice with those near you, sharing a drink, or the mana, lets you open up your home in a low-stress setting without the pressure of cooking for a crowd. These simple at-home cocktail recipes for a Cucumber Serrano Margarita or Mana Paloma make hosting a breeze – and will leave neighbors thinking you’re a natural bartender.

To discover more ways the philosophy of Mana can revitalize human connection, visit Timeleft.com.

Cucumber Serrano Margarita

  • 2          ounces Teremana Blanco or Reposado
  • 1          ounce fresh cucumber juice
  • 3/4       ounce fresh lime juice
  • 1/2       ounce agave nectar
  • 3          thin slices serrano pepper, divided
  •             ice
  •             cucumber slice, for garnish
  •             salt, for rim
  •             tajin, for rim
  1. In cocktail shaker, combine tequila, cucumber juice, lime juice, agave nectar and two slices serrano pepper; shake with ice. Strain over fresh ice into rocks glass.
  2. Garnish with cucumber slice and remaining serrano pepper slice. Rim half of glass with salt and tajin.

Mana Paloma

  •             Ice
  • 2          ounces Teremana Blanco
  • 1          ounce grapefruit juice
  • 3/4       ounce lime juice
  • 1/2       ounce simple syrup
  • club soda
  • 1          pinch salt
  •             lime wheel or grapefruit peel, for garnish
  1. In highball glass over ice, combine tequila, grapefruit juice, lime juice, simple syrup, club soda and salt. Gently stir, garnish with lime wheel or grapefruit peel and serve.

SOURCE:

Teremana Tequila

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HEALTHY LIVING

War on sunscreen: Misinformation may be undermining cancer prevention

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(Feature Impact) Despite its wide recognition as an effective tool for skin cancer prevention, many Americans still say they aren’t sure how sunscreen works. In fact, confusion about its use and misinformation persist, especially on social media.

According to a national survey conducted by Atomik Research on behalf of the nonprofit Melanoma Research Alliance (MRA), 53% of the 2,000 adult respondents said they’ve seen claims that sunscreen ingredients may be harmful while 59% reported they’re concerned about what’s in sunscreen and 38% don’t believe sunscreen is safe and effective.

This sunscreen confusion highlights a central challenge in preventing skin cancer, which is the most common form of cancer in the United States, according to the U.S. Centers for Disease Control and Prevention.

Among the various types of skin cancer, 9 out of 10, including melanoma, are linked to exposure to ultraviolet (UV) radiation, according to the MRA. The survey found most Americans have a basic understanding of the risks of sun exposure, including the more than 8 in 10 who recognize spending long hours in the sun contributes to melanoma risk. However, roughly one-quarter said they rarely or never use sunscreen when outdoors.

Reducing exposure to UV radiation lowers the risk of skin cancer, making sunscreen a key part of prevention, even during those everyday moments you may not immediately recognize as “risky,” like a short walk through a parking lot or an hour sitting in the bleachers at a sporting event.

To combat the confusion, it’s important to first understand how sunscreen works. It absorbs or blocks UV radiation from reaching the skin, preventing DNA damage that can cause cancer.

“Conflicting or incomplete information can make people less likely to wear sunscreen consistently,” said Dr. Joan Levy, chief science officer at the MRA, “but the science on sun protection is clear, and sunscreen is one of the most effective tools to prevent melanoma.”

Active ingredients in sunscreen in the U.S. undergo rigorous review by the Food and Drug Administration (FDA), which evaluates them as over-the-counter drugs – a standard which requires extensive testing and contributes to a more limited set of approved UV filters compared to Europe, where sunscreens are regulated as cosmetics.

The FDA is evaluating additional methodologies for assessing sunscreen ingredients, a process that could, according to Levy, expand the number of approved UV filters available in the U.S.

While melanoma remains the deadliest form of skin cancer, real progress is being made in melanoma research. Recent advances are improving outcomes for many patients with the disease, though approximately 50% of patients do not respond to current treatments, according to the MRA, underscoring why prevention and early detection are critical.

“Treatments such as immunotherapy have significantly improved outcomes for many melanoma patients, but we should never need to treat what we could have prevented,” Levy said.

To learn more and find strategies to protect your skin, visit CureMelanoma.org.

Photo courtesy of Shutterstock

    

SOURCE:

Melanoma Research Alliance

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HEALTHY LIVING

Steps for a lifetime of heart-healthy eating

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(Feature Impact) More than half of adults and about 60% of children in the United States have unhealthy diets, which can contribute to higher rates of health factors such as high blood pressure and obesity, and lead directly to poor health outcomes including death from chronic conditions such as cardiovascular disease.

These findings come from the American Heart Association, a global force changing the future of health for all, which published its “2026 Dietary Guidance to Improve Cardiovascular Health” in its peer-reviewed, flagship journal “Circulation” recommending Americans follow a lifelong healthy eating pattern that may reduce cardiovascular disease risk and improve quality of life based on the latest in evidence-based science.

The statement outlines nine key features of a heart-healthy dietary pattern:

  • Adjust energy intake and expenditure to achieve and maintain a healthy body weight: Try to balance how much you eat with how active you are to reach and maintain a healthy body weight.
  • Eat a variety of vegetables and fruits: Include different colors, textures and types of produce. Remember, even canned and frozen can be nutritious and affordable.
  • Choose foods made mostly with whole grains: Foods such as whole‑wheat bread, brown rice and oatmeal are typically better choices than refined grains including white bread or rice.
  • Choose healthy sources of protein: Shift from meat to plant-based sources such as legumes, including beans, peas and lentils, along with nuts and seeds; regularly consume fish and seafood; select low-fat or fat-free dairy products; and, if red meat is desired, choose lean cuts, avoid processed forms and limit portion size.
  • Choose sources of unsaturated fats: Replace saturated fats with healthy unsaturated fats, including those from nuts, seeds, avocados and nontropical plant oils.
  • Choose minimally processed foods: Go with foods close to their natural state, with minimal added commercial ingredients, rather than those that are highly processed with additives.
  • Minimize intake of added sugars: Limit the sugar-sweetened beverages you drink and the foods with added sugar you eat.
  • Choose foods low in sodium and prepare foods with minimal or no salt: Be aware of hidden sources of sodium in prepared and packaged foods, and season food with healthier options such as herbs, spices or lemon instead of salt.
  • If alcohol is not consumed, do not start; if alcohol is consumed, limit intake: Alcohol can increase your risk for high blood pressure and other health conditions, so if you don’t drink, don’t start.

“For healthy eating to be more attainable and sustainable, we recommend people focus on their overall eating pattern rather than specific nutrients or foods,” said Alice H. Lichtenstein, D.Sc., FAHA, volunteer chair of the scientific statement writing committee and senior scientist and leader of the Diet and Chronic Disease Prevention Directive at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. “Every time you choose to make a swap for a healthier alternative, you’re making a step toward a healthier life.”

While the updated guidance is specifically designed to improve cardiovascular health, it’s generally consistent with dietary recommendations for other conditions like Type 2 diabetes, kidney disease, some cancers and brain health as well due to shared risk factors, including high blood pressure, high cholesterol, high blood sugar, excess weight and reduced kidney function.

“A healthy dietary pattern can support lifelong health and well-being beyond cardiovascular health,” Lichtenstein said.

To learn more about eating for heart and brain health, visit heart.org/healthydietand talk to your health care provider about what will work best for you.

Photo courtesy of Shutterstock

    

SOURCE:

American Heart Association

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